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Johnson & Johnson
Johnson & Johnson
H1B Visa SponsorBiotechnologyHealthcarePharmaceuticals
Johnson & Johnson is a global healthcare company working across pharmaceuticals, medical devices, and consumer health. Its research and product development activities include medicines and therapies for oncology, immunology, neuroscience, and cardiopulmonary conditions, alongside MedTech solutions for cardiovascular care, orthopaedics, surgery, and vision. The company’s wider work also includes health and wellness education, large-scale manufacturing, investor activities, and global social-impact initiatives, creating opportunities across scientific, clinical, engineering, manufacturing, commercial, and corporate functions.
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Senior/Executive Director, Oncology Reverse Translation

Lead reverse-translation research at Johnson & Johnson, converting clinical observations into actionable hypotheses for cancer drug development. Build teams, platforms, and strategies that strengthen the oncology pipeline.

USUnited StatesCACaliforniaMAMassachusettsNJNew JerseyPAPennsylvania
$196,000 – $342,700 / year
HybridFull-timeSeniorEnglish RequiredTranslator

Description

  • Direct independent studies addressing high-priority mechanistic questions across oncology.
  • Set priorities across disease-focused and mechanism-focused research, including shelved programs.
  • Translate research findings into next-generation hypotheses and combination strategies with Discovery.
  • Address active mechanistic questions from translational research leads across solid and hematologic cancers.
  • Lead laboratory investigations into program efficacy, failure, and resistance.
  • Design and evaluate combination approaches to increase benefit and overcome resistance.
  • Establish and operate the laboratory while bringing disease-area program scientists together under unified leadership.
  • Oversee omics, functional and perturbation biology, in vitro and in vivo studies, and organoid platforms.
  • Contribute to translational research leadership and organization-wide scientific strategy.
  • Connect reverse translation with Discovery as the scientific liaison.
  • Collaborate with Medical Affairs and Commercial on portfolio and lifecycle priorities.
  • Advance mechanism-focused translational publications, including the Mechanism Series.
  • Mentor scientists and foster rigorous, open scientific debate.
  • Evaluate team performance by its influence on program and portfolio decisions.

Requirements

  • Doctorate in cancer biology, molecular biology, immunology, pharmacology, or a related discipline, such as a PhD, MD, or MD/PhD.
  • At least 10 years of oncology discovery or translational research experience for Senior Director roles, or 12 years for Executive Director roles, including hands-on laboratory leadership.
  • Broad expertise in mechanisms and modes of resistance, with demonstrated success converting clinical observations into testable laboratory hypotheses.
  • Experience building and managing wet-lab teams and operating omics and functional-characterization platforms.
  • Ability to work effectively between Discovery and Translational Research in a matrix spanning multiple disease areas.
  • Strong publication record as a first or senior author, together with clear scientific communication skills.
  • Preferred: expertise in multiomics, perturbation biology, organoid models, and computational data integration.
  • Preferred: experience extracting portfolio-relevant insights from shelved programs.
  • Preferred: demonstrated ability to design combination and resistance-reversal strategies across modalities.
  • Preferred: experience collaborating with Medical Affairs and Commercial on lifecycle-focused science.

Benefits

  • Pension retirement plan.
  • 401(k) savings plan.
  • Long-term incentive program.
  • 120 vacation hours per calendar year.
  • 40 sick-time hours per calendar year, increasing to 48 hours in Colorado and 56 hours in Washington.
  • 13 paid holidays, including floating holidays, per calendar year.
  • Up to 40 hours of work, personal, and family time per calendar year.
  • 480 hours of parental leave within one year of a child’s birth, adoption, or foster placement.
  • Bereavement leave of 240 hours for an immediate family member or 40 hours for an extended family member per calendar year.
  • 80 caregiver-leave hours during a rolling 52-week period.
  • 32 volunteer-leave hours per calendar year.
  • 80 military spouse time-off hours per calendar year.
  • Inclusive interviews and disability accommodations.

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