MSD
MSD

MSD is a global biopharmaceutical company advancing medicines and vaccines for major health challenges, including cancer, infectious diseases, cardiovascular and metabolic conditions, and prevention-focused care. Known as Merck & Co., Inc. in the United States, Canada, and Puerto Rico, MSD combines scientific research with development and commercial expertise to bring healthcare solutions to people and animals.

Its work spans Human Health, Animal Health, and Research & Development, creating opportunities for professionals across scientific, clinical, commercial, operational, and corporate teams. With activities in regions around the world, MSD’s careers reflect its focus on research, collaboration, inclusion, and responsible progress in global health.

Principal Scientist, Immunology Biomarker Lead – Clinical Research

Lead immunology biomarker strategy across Merck’s clinical development portfolio. Connect disease biology, precision medicine, pharmacodynamics, and clinical endpoints to guide program decisions.

Description

  • Develop integrated biomarker strategies across discovery and early- and late-stage clinical programs
  • Own biomarker strategy within cross-functional development teams
  • Represent multidisciplinary teams in governance forums
  • Use biomarker evidence to inform target validation, patient selection, portfolio prioritization, and go/no-go decisions
  • Convert disease biology and therapeutic mechanisms of action into clinically actionable biomarker plans
  • Evaluate and advance innovative biomarker methods
  • Direct biomarker sub-teams and working groups spanning clinical, discovery, translational, regulatory, biostatistics, and data science functions
  • Bring varied scientific perspectives together into aligned biomarker strategies
  • Lead biomarker analysis planning and interpret complex datasets
  • Present scientific findings to internal stakeholders, governance groups, and external audiences
  • Contribute to publications, scientific presentations, and key opinion leader engagement

Requirements

  • PhD or MD in Immunology, Biology, or a related STEM field plus 7+ years of immunology experience; alternatively, an MS with 10+ years or a BS with 14+ years of experience
  • Experience in autoimmune disease research and development or translational medicine is strongly preferred
  • Advanced knowledge of immunology and immune-mediated or inflammatory diseases
  • Experience in rheumatology, gastrointestinal or mucosal inflammation, or dermatology
  • Demonstrated success developing translational strategies that influence clinical development decisions
  • Ability to lead highly matrixed, cross-functional teams
  • Strong analytical and problem-solving skills
  • Excellent written and verbal communication abilities
  • Working knowledge of biostatistics, bioinformatics, and advanced data analytics
  • Experience advancing precision medicine strategies
  • Must reside in the United States or Puerto Rico
  • Visa sponsorship is not available
  • Willingness to travel 10% of the time

Benefits

  • Annual bonus opportunity
  • Long-term incentive, where applicable
  • Medical, dental, and vision coverage
  • Additional insurance coverage for employees and their families
  • Retirement benefits, including a 401(k) plan
  • Paid holidays
  • Vacation leave
  • Compassionate leave
  • Sick leave
  • Hybrid work options
  • Domestic relocation support

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